Antituberculous Compounds. IV. Thiosemicarbazones and Related Compounds

Thiosemicarbazones as New Antitumor Compounds

The search of new compounds with medicinal applications is promoting important therapeutic advances and generates a new scientific multidisciplinary field where chemistry, pharmacy and biomedicine overlap together with other specialities. Thiosemicarbazones are some of the studied compounds. These sulfur-containing organic substances exhibit an interesting biological activity, which has been st...

Sn(IV) Compounds Interaction with Metal-Schiff Base Complexes

The formation constants and Gibbs free energy for the interaction of RnSnClm (n = m = 2, R = Me, Ph, n-Bu or n = 4, m = 0, R = Ph) compounds as acceptors, with ML complexes (H2L = N,N'-bis(salicylidene)-2-aminobenzylamine (salabza-H2) and its derivatives, M = Mn2+ or Zn2+), as donors in N,N'-dimethylformamide (DMF) as solvent were studied. These parameters were measured by using UV-vis spectrop...

Coumarins, Xanthones and Related Compounds.

It has long been known that coumarins (α-pyrones) and xanthones (γ-pyrones) together form a large class of naturally occurring compounds exhibiting a wide range of biological activities. However, the interest of the scientific community for these secondary metabolites, as well as for their structural analogues, has never decreased since these “old compounds” are constantly generating promising—...

Pteroylglutamic acid and related compounds.

8ƒ¿-hydroxyflavinmononucleotide and Related Compounds

2•L,3•L,4•L-Triacetyl-FMN has been transformed by selec tive radical bromination into 2•L,3•L,4•L-triacetyl-8ƒ¿-bromo-FMN, and the following hydrolysis of the latter has afforded 8ƒ¿-hydroxy-FMN. The presence of the hydroxy group in the 8ƒ¿ position of 8ƒ¿-hydroxy FMN is confirmed by its acetylation into 2•L,3•L-dracetyl-8ƒ¿-acetoxyribofla vin-4•L,5•L-cyclophosphate. The absorption spectra of t...